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[脑动脉瘤破裂后神经外科入院量表预后准确性的验证]

[Validation of the prognostic accuracy of neurosurgical admission scales after rupture of cerebral aneurysms].

作者信息

Aulmann C, Steudl W I, Feldmann U

机构信息

Neurochirurgische Universitätsklinik des Saarlandes, Universität des Saarlandes, Homburg.

出版信息

Zentralbl Neurochir. 1998;59(3):171-80.

PMID:9816668
Abstract

The course of 185 patients operated for a ruptured intracranial aneurysm at the University of Saarland between 1991 and 1993 has been followed up. The main emphasis of the investigation was placed on the scrutiny of the coma scales on admission (Hunt & Hess-Scale, Glasgow Coma Scale and WFNS-Scale [= World Federation of Neurological Surgeons]) with regard to the outcome. Outcome was defined as the patients' state six months after aneurysm rupture according to the Glasgow Outcome Scale. The sensitivities, specifities and predictive values of almost all scale grades were poor. The Hunt&Hess-Scale was the one with the best correlation. By half the patients with the worst scale grades on admission had a good outcome. A gradation of the outcome with regard to the middle admission grades has not been identified. These observations have been demonstrated by using ROC (Receiver Operating Characteristic)-curves. The admission scales are not suitable to give a definite prognosis and do not justify any decision neither pro nor contra an operation. A lot of parameters besides the neurological findings have an effect on the prognosis. Additionally, unexpected complications may occur in the pre- and postoperative phase. The score values determined at the day of operation have shown a more precise prognosis than the values determined immediately after hospitalization. Therefore the evaluation of the most relevant phase could improve the prognostic value of the scales.

摘要

对1991年至1993年间在萨尔兰大学因颅内动脉瘤破裂而接受手术的185例患者的病程进行了随访。调查的重点是入院时昏迷量表(Hunt & Hess量表、格拉斯哥昏迷量表和WFNS量表[=世界神经外科医师联合会量表])与预后的关系。预后根据格拉斯哥预后量表定义为动脉瘤破裂后6个月患者的状态。几乎所有量表等级的敏感性、特异性和预测值都很差。Hunt&Hess量表的相关性最佳。入院时量表等级最差的患者中有一半预后良好。尚未确定与入院中等量表等级相关的预后分级。这些观察结果通过ROC(受试者工作特征)曲线得到了证实。入院量表不适合给出明确的预后,也不能为支持或反对手术的任何决定提供依据。除神经学检查结果外,许多参数都会影响预后。此外,术前和术后阶段可能会出现意外并发症。手术当天确定的评分值比住院后立即确定的值显示出更精确 的预后情况。因此,对最相关阶段的评估可以提高量表的预后价值。

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