Ballmer-Weber B K
Allergiestation, Dermatologische Klinik, UniversitätsSpital Zürich.
Praxis (Bern 1994). 1998 Sep 30;87(40):1293-9.
Atopic dermatitis is an important manifestation of the atopic diathesis with increasing incidence. The average lifetime prevalence in Switzerland is about 13%. The skin disease is characterised by severe itching, eczematous skin lesions with often distinctive distribution, dryness of the skin and a personal of family history of atopic diseases. The following article summarises some clinical, epidemiological, therapeutical and pathogenetical aspects of atopic dermatitis. Studies from the allergy unit of Zurich contributed to a better understanding of the disease. Thus, Storck was contributing various studies about neurovegetative and circulatory dysregulations in patients with atopic dermatitis. Furthermore, he already realised in 1955 a relation between exacerbations of eczema and the sensitisation to inhalatory allergens. Schnyder demonstrated that asthma, rhinitis and atopic dermatitis have the same genetic background and Wüthrich contributed important data about the natural history of the disease and the occurrence and relevance of total and specific IgE antibodies.
特应性皮炎是特应性素质的一种重要表现，发病率呈上升趋势。在瑞士，其终生患病率平均约为13%。这种皮肤病的特征是严重瘙痒、具有常为独特分布的湿疹性皮肤损害、皮肤干燥以及个人或家族有特应性疾病史。以下文章总结了特应性皮炎的一些临床、流行病学、治疗和发病机制方面的内容。苏黎世过敏科的研究有助于更好地理解这种疾病。因此，施托克开展了多项关于特应性皮炎患者神经植物性和循环调节功能失调的研究。此外，他在1955年就已认识到湿疹加重与吸入性过敏原致敏之间的关系。施奈德证明哮喘、鼻炎和特应性皮炎具有相同的遗传背景，而伍特里希提供了关于该疾病自然史以及总IgE和特异性IgE抗体的发生及相关性的重要数据。
