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Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus.

作者信息

Hatalski C G, Hickey W F, Lipkin W I

机构信息

Department of Neurology, University of California, Irvine 92697-4292, USA.

出版信息

J Neuroimmunol. 1998 Oct 1;90(2):128-36. doi: 10.1016/s0165-5728(98)00066-6.

DOI:10.1016/s0165-5728(98)00066-6
PMID:9817440
Abstract

The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa light chain mRNA-containing cells in brain and accumulation of virus-specific antibodies in cerebrospinal fluid. Treatment with BD-rat serum altered viral gene expression in persistently infected cultured rat glioblastoma cells. These data suggest that antibodies, produced in the brain, may influence viral gene expression.

摘要

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