Modis Y, Wierenga R
European Molecular Biology Laboratory Postfach, 10.2209 D-69012 Heidelberg, Germany.
Structure. 1998 Nov 15;6(11):1345-50. doi: 10.1016/s0969-2126(98)00134-8.
Coenzyme A (CoA) is well known for its importance in various metabolic pathways. The recent determination of the structures of several CoA-dependent N-acylating enzymes highlights the importance of the acyl-CoA molecule for intracellular regulation and reveals a novel fold. The N-acetyltransferase fold defines yet another protein superfamily and adds to the already diverse world of CoA-dependent enzymes.
辅酶A（CoA）在各种代谢途径中的重要性广为人知。最近对几种依赖辅酶A的N-酰基化酶结构的测定突出了酰基辅酶A分子对细胞内调节的重要性，并揭示了一种新的折叠结构。N-乙酰转移酶折叠结构定义了另一个蛋白质超家族，并为已经多种多样的依赖辅酶A的酶世界增添了新成员。
