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Structure and mechanism of action of the histone acetyltransferase Gcn5 and similarity to other N-acetyltransferases.组蛋白乙酰转移酶Gcn5的结构与作用机制及其与其他N-乙酰转移酶的相似性。
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2
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.酵母GCN5转录共激活因子的晶体结构及组蛋白乙酰化机制
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3
Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.组蛋白乙酰转移酶Hpa2的晶体结构：Gcn5相关N-乙酰转移酶超家族的四聚体成员。
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One HAT size fits all?一种尺寸的帽子适合所有人吗？
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GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.与GCN5相关的组蛋白N-乙酰转移酶属于一个多样化的超家族，其中包括酵母SPT10蛋白。
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Effect of lysine side chain length on histone lysine acetyltransferase catalysis.赖氨酸侧链长度对组蛋白赖氨酸乙酰转移酶催化作用的影响。
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The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.甲硫氨酸转氨途径通过调节GCN5乙酰转移酶和PGC-1α转录共激活因子来控制肝脏葡萄糖代谢。
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The microtubule-associated tau protein has intrinsic acetyltransferase activity.微管相关的 tau 蛋白具有内在的乙酰转移酶活性。
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8
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase.在枯草芽孢杆菌中，由srtN基因（原yhdZ）编码的沉默调节蛋白去乙酰化酶以及acuABC基因编码的功能可控制乙酰辅酶A合成酶的活性。
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Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.两种重要的MYST家族蛋白在锥虫的组蛋白H4K10乙酰化和端粒沉默中发挥不同作用。
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Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis.枯草芽孢杆菌中控制乙酰辅酶A合成酶（AcsA）活性的乙酰转移酶AcuA的生化与突变分析。
J Bacteriol. 2008 Jul;190(14):5132-6. doi: 10.1128/JB.00340-08. Epub 2008 May 16.

本文引用的文献

1
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.组蛋白的乙酰化和甲基化及其在RNA合成调控中的可能作用。
Proc Natl Acad Sci U S A. 1964 May;51(5):786-94. doi: 10.1073/pnas.51.5.786.
2
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.酵母GCN5转录共激活因子的晶体结构及组蛋白乙酰化机制
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8931-6. doi: 10.1073/pnas.96.16.8931.
3
The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog.血清素N - 乙酰基转移酶有序底物结合的结构基础：与双底物类似物形成的酶复合物，分辨率为1.8埃
Cell. 1999 Apr 30;97(3):361-9. doi: 10.1016/s0092-8674(00)80745-x.
4
Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism.褪黑素的生物合成：分辨率为2.5埃的血清素N-乙酰基转移酶结构揭示了一种催化机制。
Mol Cell. 1999 Jan;3(1):23-32. doi: 10.1016/s1097-2765(00)80171-9.
5
Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis.酿酒酵母GNA1，一个编码参与UDP-N-乙酰葡糖胺合成的新型乙酰转移酶的必需基因。
J Biol Chem. 1999 Jan 1;274(1):424-9. doi: 10.1074/jbc.274.1.424.
6
Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes.N-乙酰转移酶的两种晶体结构揭示了辅酶A依赖性酶的一种新折叠方式。
Structure. 1998 Nov 15;6(11):1345-50. doi: 10.1016/s0969-2126(98)00134-8.
7
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase.一种与GCN5相关的N-乙酰基转移酶的晶体结构：粘质沙雷氏菌氨基糖苷3-N-乙酰基转移酶
Cell. 1998 Aug 21;94(4):439-49. doi: 10.1016/s0092-8674(00)81585-8.
8
Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.组蛋白乙酰转移酶Hat1的结构：GCN5相关N-乙酰转移酶超家族的范例
Cell. 1998 Aug 21;94(4):427-38. doi: 10.1016/s0092-8674(00)81584-6.
9
Crystal structure of the anti-fungal target N-myristoyl transferase.抗真菌靶点N-肉豆蔻酰转移酶的晶体结构
Nat Struct Biol. 1998 Mar;5(3):213-21. doi: 10.1038/nsb0398-213.
10
Linking histone acetylation to transcriptional regulation.将组蛋白乙酰化与转录调控联系起来。
Cell Mol Life Sci. 1998 Jan;54(1):6-20. doi: 10.1007/s000180050121.

Structure and mechanism of action of the histone acetyltransferase Gcn5 and similarity to other N-acetyltransferases.

作者信息

Sternglanz R, Schindelin H

机构信息

Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA.

出版信息

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8807-8. doi: 10.1073/pnas.96.16.8807.

DOI:10.1073/pnas.96.16.8807
PMID:10430845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33686/
Abstract
摘要