生长激素和胰岛素样生长因子在免疫系统中的作用。
The role of growth hormone and insulin-like growth factors in the immune system.
作者信息
van Buul-Offers S C, Kooijman R
机构信息
Wilhelmina Children's Hospital, Department of Endocrinology, Utrecht, The Netherlands.
出版信息
Cell Mol Life Sci. 1998 Oct;54(10):1083-94. doi: 10.1007/s000180050237.
Growth hormone (GH) and insulin-like growth factor I (IGF-I) can modulate the development and function of the immune system. In this chapter, we present data on the expression of receptors for GH and IGFs and the in vitro and in vivo effects of these proteins. We show that expression of GH and IGFs in the immune system opens up the possibility that these proteins are not only involved in endocrine control of the immune system but can also play a role as local growth and differentiation factors (cytokines). Endocrine control of GH could be direct or mediated via endocrine or autocrine/paracrine IGF-I. In addition, GH can act as an autocrine or paracrine factor itself. Furthermore, IGF-I in the immune system has been shown to be regulated by cytokines, such as interleukin-1 and interferon-gamma, alluding to a cytokine-like function of IGF-I. In addition to data on the function of GH and IGF-I in the immune system, we present new findings which imply a possible function of IGF-II and IGF-binding proteins.
生长激素（GH）和胰岛素样生长因子I（IGF-I）可调节免疫系统的发育和功能。在本章中，我们展示了关于GH和IGF受体表达以及这些蛋白质在体外和体内作用的数据。我们表明，GH和IGF在免疫系统中的表达揭示了这些蛋白质不仅参与免疫系统的内分泌控制，还可能作为局部生长和分化因子（细胞因子）发挥作用的可能性。GH的内分泌控制可能是直接的，或通过内分泌或自分泌/旁分泌的IGF-I介导。此外，GH本身也可作为自分泌或旁分泌因子发挥作用。此外，免疫系统中的IGF-I已被证明受细胞因子如白细胞介素-1和干扰素-γ的调节，这暗示了IGF-I具有类似细胞因子的功能。除了关于GH和IGF-I在免疫系统中功能的数据外，我们还展示了一些新发现，这些发现暗示了IGF-II和IGF结合蛋白可能具有的功能。
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