Perry B P, Gregg C M, Myers S, Lilly S, Mann K P, Prieto V
Division of Otolaryngology-Head and Neck Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Ear Nose Throat J. 1998 Oct;77(10):855-8.
Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytosis of unknown etiology that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases, most often in the head and neck. Characteristic histologic findings include emperiopolesis (engulfment) of lymphocytes and S-100 protein positivity. Treatment of Rosai-Dorfman disease is unnecessary unless the disorder becomes life- or organ-threatening, since the disease will resolve spontaneously in most patients. We present what, to the best of our knowledge, is the first reported case of Rosai-Dorfman disease limited to the skin in a patient infected with human immunodeficiency virus. SHML is described and diagnostic and therapeutic measures are reviewed.
罗萨伊-多夫曼病，即伴有巨大淋巴结病的窦性组织细胞增多症（SHML），是一种病因不明的罕见组织细胞增多症，最常累及颈部淋巴结。30%至40%的病例会出现结外受累，最常见于头颈部。特征性组织学表现包括淋巴细胞的吞噬现象（吞噬作用）和S-100蛋白阳性。除非该疾病对生命或器官构成威胁，否则无需对罗萨伊-多夫曼病进行治疗，因为大多数患者的疾病会自发缓解。据我们所知，我们报告了首例人类免疫缺陷病毒感染患者中局限于皮肤的罗萨伊-多夫曼病病例。本文描述了SHML并综述了诊断和治疗措施。
