Maeda M, Fukui A, Nakamura T, Inada Y, Tamai S, Haga S, Tatsumi K, Yamamoto H, Ogata S, Iwata H, Ikada Y
Department of Orthopedic Surgery, Nara Medical University, Kashihara City, Japan.
J Reconstr Microsurg. 1998 Oct;14(7):491-8. doi: 10.1055/s-2007-1000212.
To improve cell attachment without inducing thrombogenesis, the authors coated the inner surface of polytetrafluoroethylene (PTFE) prostheses (I.D.: 1 mm; length: 10 mm; wall thickness: 0.5 mm; fibril length: 30 microm) with polyacrylamide (PAA), known to have a strong antithrombotic effect (PAA-PTFE). They implanted the prostheses into the abdominal aorta of rats, and retrieved them at intervals of up to 9 months. Graft healing was observed under light and scanning electron microscopy. All the inner surfaces of the grafts examined were barely covered with fibrin or platelets. The PAA-coated fibers had many projections, in contrast to the original PTFE prostheses. Neo-endothelium was observed to be directly attached to these structural fibers of the PAA-PTFE grafts. Restoration of the neointima was also observed in these vascular prostheses.
为了在不诱导血栓形成的情况下改善细胞附着，作者用已知具有强大抗血栓作用的聚丙烯酰胺（PAA）涂覆聚四氟乙烯（PTFE）假体的内表面（内径：1毫米；长度：10毫米；壁厚：0.5毫米；纤维长度：30微米）（PAA-PTFE）。他们将假体植入大鼠腹主动脉，并在长达9个月的间隔时间后取出。在光学显微镜和扫描电子显微镜下观察移植物愈合情况。所有检查的移植物内表面几乎没有被纤维蛋白或血小板覆盖。与原始的PTFE假体相比，PAA涂层纤维有许多突起。观察到新内膜直接附着在PAA-PTFE移植物的这些结构纤维上。在这些血管假体中也观察到了新内膜的恢复。
