Robinson P H, Bartels H L, van der Lei B
Department of Plastic and Reconstructive Surgery, University Hospital, Groningen, The Netherlands.
J Reconstr Microsurg. 1989 Oct;5(4):331-6. doi: 10.1055/s-2007-1006882.
Many studies have been undertaken on the experimental evaluation of microarterial polytetrafluoroethylene (PTFE) prostheses of short length. This study was undertaken to obtain insight into the performance of longer microvascular PTFE prostheses, which would be of more clinical utility. Microvascular PTFE prostheses of 10 cm in length (n = 8) were implanted into the rat abdominal aorta, fixed in a loop, and were compared regarding patency and healing with microvascular PTFE prostheses of 1 cm in length (n = 8) at three months after implantation (all prostheses: I.D.--1.5 mm, fibril length--30 microns). At three months, all prostheses, except one 10-cm prosthesis, were patent. In all PTFE microarterial prostheses, healing was observed only at the anastomotic sites with ingrowth of endothelial cells for a few millimeters into the lumen. There was no evidence of healing in the central areas of the prostheses. It was concluded that microvascular PTFE prostheses of useful clinical length show encouraging patency rates in the rat, despite poor endothelial cover. For possible clinical application of microvascular PTFE prostheses, further experimental studies should be undertaken to improve their healing capabilities.
已经对短长度的微动脉聚四氟乙烯（PTFE）假体进行了许多实验评估研究。本研究旨在深入了解更长的微血管PTFE假体的性能，这类假体将具有更大的临床应用价值。将长度为10厘米的微血管PTFE假体（n = 8）植入大鼠腹主动脉，固定成环状，并在植入后三个月将其通畅性和愈合情况与长度为1厘米的微血管PTFE假体（n = 8）进行比较（所有假体：内径——1.5毫米，原纤维长度——30微米）。三个月时，除了一个10厘米长的假体，所有假体均保持通畅。在所有PTFE微动脉假体中，仅在吻合部位观察到愈合，内皮细胞长入管腔几毫米。在假体的中央区域没有愈合的迹象。得出的结论是，具有临床实用长度的微血管PTFE假体在大鼠中显示出令人鼓舞的通畅率，尽管内皮覆盖较差。对于微血管PTFE假体的可能临床应用，应进行进一步的实验研究以提高其愈合能力。
