Jerry L M, Rowden G, Cano P O, Phillips T M, Deutsch G F, Capek A, Hartmann D, Lewis M G
Scand J Immunol. 1976;5(6-7):845-59. doi: 10.1111/j.1365-3083.1976.tb03034.x.
Circulating immune complexes were detected in 62 individuals with malignant melanoma by precipitation with isolated human C1q and polyclonal rheumatoid factors. In 56 patients the C1q deviation assay showed low to moderate levels of complexes, with increased amounts with advancing stage of disease. Both heavy (greater than 19S) and intermediate (7S to 19S) varieties were present, and complexes containing tumor antigen-antibody or antibody-anti-antibody were identified. Complexes were found in the kidneys of one patient with malignancy and the nephrotic syndrome and in two further patients with melanoma in whom there were no clinical manifestations of nephrosis. Serial determinations in 51 patients showed slow cyclic variations in the levels of complexes and fluctuations in response to therapy. The coexistence of anti-antibodies, immune complex disease, and anergy in melanoma patients may indicate a deranged immune regulation consequent to chronic antigenic stimulation by the tumor.
通过用人C1q分离物和多克隆类风湿因子沉淀法，在62例恶性黑色素瘤患者中检测到循环免疫复合物。在56例患者中，C1q偏差试验显示复合物水平低至中度，且随着疾病进展量增加。存在重（大于19S）和中（7S至19S）两种类型，并且鉴定出含有肿瘤抗原 - 抗体或抗体 - 抗抗体的复合物。在1例患有恶性肿瘤和肾病综合征的患者以及另外2例无肾病临床表现的黑色素瘤患者的肾脏中发现了复合物。对51例患者的连续测定显示复合物水平呈缓慢的周期性变化以及对治疗反应的波动。黑色素瘤患者中抗抗体、免疫复合物疾病和无反应性的共存可能表明肿瘤慢性抗原刺激导致免疫调节紊乱。
