Mittal N, Gupta N, Saksena S, Goyal N, Roy U, Rastogi A K
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Life Sci. 1998;63(20):1823-34. doi: 10.1016/s0024-3205(98)00456-1.
The prevalent drugs for treatment of kala azar viz. sodium stibogluconate (SSG) and pentamidine cause severe toxic side effects and acute immunosuppression in the treated individuals. Picroliv, a standardized mixture of iridoid glycosides, prepared from the alcoholic extract of the root and rhizome of Picrorhiza kurroa has shown strong hepatoprotective activity against several models of hepatotoxicity. Therefore, the present study was undertaken with an objective to study the effects of Picroliv (12.5 mg/kg x 7 days oral) alone and in combination with SSG on parasitemia, lipid peroxidation and hepatic marker enzymes of golden hamsters during Leishmania donovani infection. The results indicated a marked hepatoprotective effect of Picroliv in terms of biochemical markers, and a significant antileishmanial activity implying that it can be utilized as an adjunct to chemotherapy or in combination therapy of kala azar along with sodium stibogluconate, thus enhancing the efficacy of antileishmanials.
用于治疗黑热病的常用药物，即葡萄糖酸锑钠（SSG）和喷他脒，会在接受治疗的个体中引起严重的毒副作用和急性免疫抑制。苦味叶下珠素是一种环烯醚萜苷的标准化混合物，由胡黄连根和根茎的乙醇提取物制备而成，已显示出对多种肝毒性模型具有强大的肝脏保护活性。因此，本研究旨在探讨苦味叶下珠素（12.5毫克/千克，口服7天）单独使用以及与SSG联合使用对杜氏利什曼原虫感染期间金黄仓鼠的寄生虫血症、脂质过氧化和肝脏标志物酶的影响。结果表明，苦味叶下珠素在生化指标方面具有显著的肝脏保护作用，并且具有显著的抗利什曼原虫活性，这意味着它可以用作化疗的辅助药物，或与葡萄糖酸锑钠联合用于黑热病的联合治疗，从而提高抗利什曼原虫药物的疗效。
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