Tsuchida K, Okayama N, Miyata M, Joh T, Yokoyama Y, Itoh M, Kobayashi K, Nakamura T
First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan.
Am J Gastroenterol. 1998 Nov;93(11):2235-8. doi: 10.1111/j.1572-0241.1998.00622.x.
We report a case of carcinoma in solitary rectal ulcer syndrome. The diagnosis was made by colonoscopic appearance and biopsy. A tumor measuring 0.9 x 0.6 cm was found in a resected solitary rectal ulcer. The lesion exhibited typical histological features of solitary rectal ulcer syndrome, with a well differentiated adenocarcinoma invading submucosal layers and some dysplastic glands. We believe that the adenocarcinoma represents a malignant transformation from solitary rectal ulcer syndrome, because similar to longstanding chronic idiopathic colitis, colorectal dysplasia and carcinoma may develop.
我们报告一例孤立性直肠溃疡综合征合并癌的病例。诊断依据结肠镜下表现及活检做出。在切除的孤立性直肠溃疡中发现一个大小为0.9×0.6厘米的肿瘤。该病变呈现出孤立性直肠溃疡综合征的典型组织学特征，伴有高分化腺癌侵犯黏膜下层及一些发育异常的腺体。我们认为该腺癌代表了孤立性直肠溃疡综合征的恶变，因为与长期慢性特发性结肠炎类似，结直肠发育异常及癌可能会发生。
