针对脑苷脂的抗血清会产生反复的癫痫样活动。
Antiserum to brain gangliosides produces recurrent epileptiform activity.
作者信息
Karpiak S E, Graf L, Rapport M M
出版信息
Science. 1976 Nov 12;194(4266):735-7. doi: 10.1126/science.982041.
PMID:982041
Abstract
A single injection of 10 microliters of antiserum to total brain ganglioside onto (and into) the sensorimotor cortex of the rat resulted in recurrent spiking in the cortical electroencephalogram, lasting from 7 to 17 days. Absorption of antibody with pure monosialoganglioside (GM1) completely abosished the effect. Spiking was reactivated after 4 weeks by intramuscular injection of pentylenetetrazole.
摘要
向大鼠的感觉运动皮层注射（并注入）10微升全脑神经节苷脂抗血清后，皮层脑电图出现反复尖峰，持续7至17天。用纯单唾液酸神经节苷脂（GM1）吸收抗体可完全消除这种效应。4周后，通过肌肉注射戊四氮可使尖峰再次出现。
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