神经精神性狼疮的发病机制。
The pathogenesis of neuropsychiatric lupus.
作者信息
Denburg J A, Temesvari P
出版信息
Can Med Assoc J. 1983 Feb 1;128(3):257-60.
Abstract
Neuropsychiatric lupus is a frequent and serious complication of systemic lupus erythematosus. Although its pathogenesis has not been fully elucidated several mechanisms based on findings in animals and humans have been proposed: cerebral vasculitis; the cross-reaction of lymphocytotoxic antibodies with brain tissue; choroid plexus dysfunction; and the blocking of neurotransmission by noncytotoxic antibodies. Any or all of these mechanisms may be active in a particular patient at a given time.
摘要
神经精神性狼疮是系统性红斑狼疮常见且严重的并发症。尽管其发病机制尚未完全阐明，但基于动物和人类研究结果已提出了几种机制：脑血管炎；淋巴细胞毒性抗体与脑组织的交叉反应；脉络丛功能障碍；以及非细胞毒性抗体对神经传递的阻断。在特定时间，这些机制中的任何一种或全部都可能在特定患者中起作用。
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