Dua H S, Azuara-Blanco A, Hossain M, Lloyd J
Department of Ophthalmology, Queen's Medical Centre-University Hospital, Nottingham, United Kingdom.
Cornea. 1998 Nov;17(6):675-7. doi: 10.1097/00003226-199811000-00018.
To describe the clinical presentation and outcome of two cases with presumed non-Acanthamoeba amebic keratitis.
Case reports.
Both patients presented with typical symptoms and signs of Acanthamoeba keratitis. The patients' soft contact lenses, lens cases, open solutions, and conjunctival samples were cultured. Diagnosis of non-Acanthamoeba amebic keratitis was based on the presence of keratitis and amebic growth from patients' contact lenses of the affected eyes. Amebic culture from the contralateral contact lens was negative. Vahlkampfia cysts were identified in case 1, and Naegleria cysts in case 2. Topical treatment with polyhexamethylene biguanide and propamidine resolved the keratitis in case 1. Case 2 was lost to follow-up.
Non-Acanthamoeba amebic keratitis was diagnosed in two patients based on the clinical presentation (resembling Acanthamoeba keratitis), culture of the contact lens, and response to antiamebic treatment (in one case). Keratitis associated with Naegleria contamination of contact lenses has not been previously reported.
描述两例疑似非棘阿米巴性阿米巴角膜炎的临床表现及转归。
病例报告。
两名患者均表现出典型的棘阿米巴角膜炎症状和体征。对患者的软性隐形眼镜、镜盒、未开封的护理液及结膜样本进行培养。非棘阿米巴性阿米巴角膜炎的诊断基于角膜炎的存在以及患眼隐形眼镜上有阿米巴生长。对侧隐形眼镜的阿米巴培养结果为阴性。病例1中鉴定出瓦氏耐格里阿米巴囊肿，病例2中鉴定出福氏耐格里阿米巴囊肿。病例1局部应用聚六亚甲基双胍和丙脒腙后角膜炎得到缓解。病例2失访。
基于临床表现（类似棘阿米巴角膜炎）、隐形眼镜培养结果以及抗阿米巴治疗反应（其中1例），两名患者被诊断为非棘阿米巴性阿米巴角膜炎。此前尚未有与隐形眼镜被耐格里属阿米巴污染相关的角膜炎报道。
