Warowna-Grześkiewicz M, Fijałek Z
Department of Inorganic Chemistry and Analytical Chemistry, Medical University of Warsaw, Poland.
Acta Pol Pharm. 1998 Jul-Aug;55(4):263-6.
Differential pulse polarography was used to study the electrode behavior of zinc (II) in various stock solutions. In view of the surfactants like methylcellulose derivatives present in the pharmaceutical preparations examined, which affected the course of the polarograms recorded, 0.5 mol l-1 ammonium buffer, pH 10.0, was found to be an optimum solution for the study. In a strong alkaline solution, zine currents were no longer suppressed by the methylcellulose derivatives. To compare the polarographic data obtained for "Cincol", "Oculosan" and "Visine Sensitive" eye drops, zinc (II) was determined in those eye drops by atomic absorption spectrometry without mineralization. Statistical evaluation of the data showed the DPP procedure developed to be characterized by satisfactory accuracy and precision (RSD : 0.93% ("Cincol"), 0.82% ("Oculosan"), 0.82%; ("Visine Sensitive")).
采用差分脉冲极谱法研究了锌（II）在各种储备溶液中的电极行为。鉴于所检测的药物制剂中存在甲基纤维素衍生物等表面活性剂，它们会影响记录的极谱图过程，发现0.5 mol l-1 pH 10.0的铵缓冲液是进行该研究的最佳溶液。在强碱性溶液中，甲基纤维素衍生物不再抑制锌电流。为了比较“辛可”、“眼生素”和“敏感视明”滴眼液的极谱数据，采用无矿化的原子吸收光谱法测定了这些滴眼液中的锌（II）。数据的统计评估表明，所开发的差分脉冲极谱法具有令人满意的准确度和精密度（相对标准偏差：“辛可”为0.93%，“眼生素”为0.82%，“敏感视明”为0.82%）。
