Shikano T, Ohkawa M, Nakadate H, Hatae Y, Takeda T
Department of Pediatrics, Kohnan Hospital, Sapporo, Japan.
Acta Paediatr Jpn. 1998 Oct;40(5):474-8. doi: 10.1111/j.1442-200x.1998.tb01972.x.
We experienced three patients with CD30+ diffuse large cell lymphoma having chromosomal abnormalities. The first patient was an 8-year-old girl with bilateral cervical lymphadenopathy. A biopsy of a cervical lymph node revealed diffuse large cell lymphoma (stage III), positive for CD30 and a chromosomal abnormality, t(2;5). She attained a remission and is now in complete remission 108 months after diagnosis, despite frequent relapses. The second patient was a 13-year-old boy with right axillar and supraclavicular lymph-node adenopathy. A biopsy of a cervical lymph node revealed diffuse large cell lymphoma (stage III), positive for CD30 and a chromosomal abnormality, t(2;5). He attained remission and was in continuous first remission 112 months after diagnosis. The third patient was an 11-year-old boy with fever and bilateral cervical lymph node revealed diffuse large cell lymphoma (stage III), positive for CD30 and chromosomal abnormality without t(2;5). He showed a very aggressive clinical course. Only the patients with Ki-1 lymphoma having t(2;5) survived over 100 months from the diagnosis, despite the advanced stage of the disease. These findings and a review of the literature showed that the presence or absence of t(2;5) may influence the outcome of Ki-1 lymphoma.
我们遇到了3例患有染色体异常的CD30+弥漫性大细胞淋巴瘤患者。首例患者是一名8岁女孩，双侧颈部淋巴结肿大。颈部淋巴结活检显示为弥漫性大细胞淋巴瘤（III期），CD30阳性且有染色体异常t(2;5)。尽管频繁复发，但她获得了缓解，目前在诊断后108个月处于完全缓解状态。第二例患者是一名13岁男孩，右腋窝和锁骨上淋巴结肿大。颈部淋巴结活检显示为弥漫性大细胞淋巴瘤（III期），CD30阳性且有染色体异常t(2;5)。他获得了缓解，在诊断后112个月处于持续的首次缓解状态。第三例患者是一名11岁男孩，发热，双侧颈部淋巴结显示为弥漫性大细胞淋巴瘤（III期），CD30阳性且有染色体异常但无t(2;5)。他表现出非常侵袭性的临床病程。尽管疾病处于晚期，但只有患有t(2;5)的Ki-1淋巴瘤患者从诊断起存活超过100个月。这些发现以及文献回顾表明，t(2;5)的有无可能影响Ki-1淋巴瘤的预后。
