Palus J, Dziubałtowska E, Rydzyński K
Nofer Institute of Occupational Medicine, Department of Toxicology and Carcinogenesis, Lódź, Poland.
Acta Biochim Pol. 1998;45(2):605-10.
Single-strand breaks (SSB) and DNA repair were detected in peripheral lymphocytes derived from workers of a furniture factory in a non-polluted region of Poland. The workers were exposed to wood dust (n = 19), or to the dust and varnishes or lacquers together (n = 5). Four groups were studied simultaneously: (a) exposed workers smokers of cigarettes (n = 14), (b) nonexposed smokers--control (n = 14), (c) exposed workers' nonsmokers (n = 14), (d) exposed nonsmokers (n = 10). In exposed workers DNA SSB and DNA repair were statistically significantly increased. DNA SSB was clearly higher in the smoking workers than in the smoking controls. Cigarette smoking itself has produced no evident increase in the frequency of DNA SSB in the control group. Occupational exposure had a significant effect on DNA repair in non stimulated lymphocytes both in smoking and nonsmoking workers.
在波兰一个无污染地区的一家家具厂工人的外周血淋巴细胞中检测到单链断裂（SSB）和DNA修复情况。这些工人接触木屑（n = 19），或同时接触木屑和清漆或漆（n = 5）。同时研究了四组：（a）接触木屑的吸烟工人（n = 14），（b）未接触木屑的吸烟对照组（n = 14），（c）接触木屑的不吸烟工人（n = 14），（d）未接触木屑的不吸烟工人（n = 10）。在接触木屑的工人中，DNA单链断裂和DNA修复在统计学上显著增加。吸烟的接触木屑工人的DNA单链断裂明显高于吸烟对照组。吸烟本身在对照组中并未使DNA单链断裂频率明显增加。职业暴露对吸烟和不吸烟工人未受刺激的淋巴细胞中的DNA修复均有显著影响。
