过氧化物酶体增殖物激活受体γ3信使核糖核酸：一种从独立启动子转录而来的独特过氧化物酶体增殖物激活受体γ信使核糖核酸亚型。
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter.
作者信息
Fajas L, Fruchart J C, Auwerx J
机构信息
INSERM U 325, Département d'Athérosclérose, Institut Pasteur, Lille, France.
出版信息
FEBS Lett. 1998 Oct 30;438(1-2):55-60. doi: 10.1016/s0014-5793(98)01273-3.
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
PPARγ是核受体过氧化物酶体增殖物激活受体（PPAR）亚家族的成员。到目前为止，在哺乳动物中已知两种PPARγ亚型，即PPARγ1和PPARγ2。我们描述了一种新型人类PPARγ亚型PPARγ3的结构。PPARγ3 mRNA是从位于外显子A2 5'端的一个新型启动子转录而来的。PPARγ3 mRNA的表达仅限于脂肪组织和大肠。与人类PPARγ1和-2相似，PPARγ3被噻唑烷二酮类和前列腺素J衍生物激活，并以高亲和力与PPRE结合。
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