Danen E H, Lafrenie R M, Miyamoto S, Yamada K M
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA.
Cell Adhes Commun. 1998;6(2-3):217-24. doi: 10.3109/15419069809004477.
Members of the integrin family of adhesion receptors mediate interactions of cells with the extracellular matrix. Besides their role in tissue morphogenesis by anchorage of cells to basement membranes and migration along extracellular matrix proteins, integrins are thought to play a key role in mediating the control of gene expression by the extracellular matrix. Studies over the past 10 years have shown that integrin-mediated cell adhesion can trigger signal transduction cascades involving translocation of proteins and protein tyrosine phosphorylation events. In this review, we discuss approaches used in our lab to study early events in integrin signalling as well as further downstream changes.
黏附受体整合素家族的成员介导细胞与细胞外基质的相互作用。除了通过将细胞锚定在基底膜以及沿细胞外基质蛋白迁移而在组织形态发生中发挥作用外，整合素还被认为在介导细胞外基质对基因表达的控制中起关键作用。过去10年的研究表明，整合素介导的细胞黏附可触发涉及蛋白质转位和蛋白质酪氨酸磷酸化事件的信号转导级联反应。在这篇综述中，我们讨论了我们实验室用于研究整合素信号传导早期事件以及进一步下游变化的方法。
