Pelloux H, Brun E, Vernet G, Marcillat S, Jolivet M, Guergour D, Fricker-Hidalgo H, Goullier-Fleuret A, Ambroise-Thomas P
Département de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Grenoble, France.
Diagn Microbiol Infect Dis. 1998 Oct;32(2):69-73. doi: 10.1016/s0732-8893(98)00077-7.
The determination of specific anti-Toxoplasma gondii IgG avidity has been proposed to improve the determination of the date of toxoplasmic seroconversion in pregnant women. In this study, we adapted this serological technique to the Vidas system (bioMérieux) using 6 M urea as the dissociating agent. We studied 356 sera, including 42 sequential sera from sero-conversions in pregnant women. Our results show that the test is easy to use, and that an avidity index higher than 0.300 allows the exclusion of a recent infection acquired less than 4 months before serum sampling.
有人提出测定抗弓形虫IgG抗体亲和力有助于改进孕妇弓形虫血清转化日期的判定。在本研究中，我们将该血清学技术应用于Vidas系统（生物梅里埃公司），使用6M尿素作为解离剂。我们研究了356份血清，其中包括42份来自孕妇血清转化过程中的连续血清样本。我们的结果表明，该检测方法易于使用，且抗体亲和力指数高于0.300时可排除在血清采样前不到4个月获得的近期感染。
