Andriessen J W, Brunekreef B, Roemer W
Department of Environmental Sciences, Environmental and Occupational Health Group, University of Wageningen, Wageningen, The Netherlands.
Clin Exp Allergy. 1998 Oct;28(10):1191-200. doi: 10.1046/j.1365-2222.1998.00322.x.
Living in a damp home has been associated with impaired respiratory health in previous studies, but objective data on lung function variability and atopy have been lacking from most studies.
Data collected in the winter of 1993-1994 in the framework of the PEACE study (Pollution Effects on Asthmatic Children in Europe) were used to study the association between home dampness and Peak Flow (PEF) variability, frequency of respiratory symptoms and relief medication use during the period of observation.
Children were selected with a screening questionnaire on the basis of positive answers to questions on symptoms of asthma and chronic cough. Children were instructed to perform PEF measurements with Miniwright PEF meters twice daily over a period of 2 months. Parents kept diaries on respiratory symptoms and medication use of their children. Data on demographic and housing characteristics were derived from a parent-administered questionnaire. As indicators for home dampness reported moisture stains and moulds were used. Children were tested for atopy with skin-prick tests. Data from 1614 children from 13 centres in 10 different countries were available for analysis. Linear regression models and prevalence rate ratios were used to investigate the association between home dampness and PEF variability and the period prevalence of cough, phlegm, lower and upper respiratory symptoms and bronchodilator use.
In atopic children, PEF variability was positively related to self-reported moulds but not to moisture stains. The period prevalence of cough and upper respiratory symptoms was significantly higher in children living in houses with reported moulds, compared with 'dry' homes.
These results show that self-reported moulds in homes are associated with objective as well as subjective markers of airway lability in European children with chronic respiratory symptoms.
以往研究表明,居住在潮湿的家中与呼吸健康受损有关,但大多数研究缺乏关于肺功能变异性和特应性的客观数据。
利用1993 - 1994年冬季在PEACE研究(欧洲污染对哮喘儿童的影响)框架内收集的数据,研究家庭潮湿与观察期内峰值呼气流速(PEF)变异性、呼吸道症状频率和缓解药物使用之间的关联。
通过筛查问卷,根据对哮喘和慢性咳嗽症状问题的肯定回答选择儿童。指导儿童使用Miniwright PEF仪,在2个月内每天进行两次PEF测量。家长记录孩子的呼吸道症状和药物使用情况。人口统计学和住房特征数据来自家长填写的问卷。使用报告的水渍和霉菌作为家庭潮湿的指标。通过皮肤点刺试验对儿童进行特应性检测。来自10个不同国家13个中心的1614名儿童的数据可供分析。使用线性回归模型和患病率比来研究家庭潮湿与PEF变异性以及咳嗽、咳痰、下呼吸道和上呼吸道症状及支气管扩张剂使用的期间患病率之间的关联。
在特应性儿童中,PEF变异性与自我报告的霉菌呈正相关,与水渍无关。与“干燥”家庭相比,报告有霉菌的房屋中儿童咳嗽和上呼吸道症状的期间患病率显著更高。
这些结果表明,欧洲有慢性呼吸道症状的儿童家中自我报告的霉菌与气道易激性的客观和主观指标均有关联。