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恒定链的Ii41亚型在T细胞受体转基因小鼠中介导阳性和阴性选择事件。

The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.

作者信息

Wright R J, Bikoff E K, Stockinger B

机构信息

Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill, London, UK.

出版信息

Immunology. 1998 Nov;95(3):309-13. doi: 10.1046/j.1365-2567.1998.00595.x.

DOI:10.1046/j.1365-2567.1998.00595.x
PMID:9824491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1364394/
Abstract

The functional role of invariant chain in T-cell selection events and antigen presentation is well established. The invariant chain gene encodes differentially spliced isoforms, Ii31 and Ii41. The Ii41 isoform has been described to increase the efficiency of antigen presentation. We have analysed the effect of the Ii41 isoform on positive and negative selection of transgenic CD4 T cells with specificity for a natural self antigen (C5) which are crucially dependent on invariant chain for their development and functional antigen recognition. The data show that Ii41 fully substitutes for wild-type invariant chain in both positive and negative selection events during functional maturation of T cells with specificity for a natural, blood-borne self antigen.

摘要

恒定链在T细胞选择事件和抗原呈递中的功能作用已得到充分证实。恒定链基因编码差异剪接的异构体Ii31和Ii41。Ii41异构体已被描述为可提高抗原呈递效率。我们分析了Ii41异构体对具有天然自身抗原（C5）特异性的转基因CD4 T细胞的阳性和阴性选择的影响，这些细胞的发育和功能性抗原识别关键依赖于恒定链。数据表明，在对天然血源自身抗原有特异性的T细胞功能成熟过程中，Ii41在阳性和阴性选择事件中完全替代了野生型恒定链。

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本文引用的文献

1
Both invariant chain isoforms Ii31 and Ii41 promote class II antigen presentation.恒定链同种型Ii31和Ii41均促进II类抗原呈递。
Int Immunol. 1997 Jul;9(7):983-91. doi: 10.1093/intimm/9.7.983.
2
In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM.在缺乏恒定链的情况下，HLA - DR分子会展示出一系列独特的肽段，这会受到HLA - DM存在与否的影响。
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5772-7. doi: 10.1073/pnas.94.11.5772.
3
In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.由MHC II类相关恒定链的p41亚型介导的体内功能。
J Immunol. 1997 Jan 1;158(1):187-99.
4
Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.恒定链和DM编辑主要组织相容性复合体（MHC）II类分子的自身肽呈递。
J Exp Med. 1996 Nov 1;184(5):1747-53. doi: 10.1084/jem.184.5.1747.
5
Phenotype and function of CD4+ T cells in mice lacking invariant chain.缺乏恒定链的小鼠中CD4 + T细胞的表型和功能
J Immunol. 1996 Mar 15;156(6):2133-42.
6
Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.主要组织相容性复合体II类相关p41恒定链片段是溶酶体组织蛋白酶L的强效抑制剂。
J Exp Med. 1996 Apr 1;183(4):1331-8. doi: 10.1084/jem.183.4.1331.
7
The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.恒定链是主要组织相容性复合体II类分子细胞内运输和功能所必需的。
J Exp Med. 1994 Feb 1;179(2):681-94. doi: 10.1084/jem.179.2.681.
8
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.缺乏恒定链表达的小鼠中主要组织相容性复合体II类组装、运输、肽获取及CD4+ T细胞选择存在缺陷。
J Exp Med. 1993 Jun 1;177(6):1699-712. doi: 10.1084/jem.177.6.1699.
9
Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.针对一种血源性自身抗原的主要组织相容性复合体II类限制性T细胞中耐受诱导的机制。
J Exp Med. 1994 Dec 1;180(6):2089-99. doi: 10.1084/jem.180.6.2089.
10
Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain.在缺乏恒定链的情况下，MHC II类多肽对肽段的获取
J Immunol. 1995 Feb 1;154(3):1048-56.