Interleukin 12 and Th1 responses in inflammatory bowel disease.
作者信息
Pallone F, Monteleone G
机构信息
Cattedra di Gastroenterologia, Dipartimento di Medicina Sperimentale, Policlinico Universitario, Via T. Campanella, 88100 Catanzaro, Italy.
出版信息
Gut. 1998 Dec;43(6):735-6. doi: 10.1136/gut.43.6.735.
Abstract
摘要
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Interleukin 12 and Th1 responses in inflammatory bowel disease.白细胞介素12与炎症性肠病中的Th1反应
Gut. 1998 Dec;43(6):735-6. doi: 10.1136/gut.43.6.735.
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本文引用的文献
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Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease.克罗恩病早期及慢性回肠病变中不同的细胞因子模式。
Gastroenterology. 1997 Jul;113(1):118-26. doi: 10.1016/s0016-5085(97)70116-1.
2
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells.白细胞介素12由克罗恩病肠道固有层单核细胞表达并主动释放。
Gastroenterology. 1997 Apr;112(4):1169-78. doi: 10.1016/s0016-5085(97)70128-8.
3
Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.克罗恩病患者肠道中1型辅助性T细胞优势及白细胞介素-12表达
Am J Pathol. 1997 Mar;150(3):823-32.
4
Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation.相互的干扰素-γ和转化生长因子-β反应调节黏膜炎症的发生。
Immunol Today. 1997 Feb;18(2):61-4. doi: 10.1016/s0167-5699(97)01000-1.
5
Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity.白细胞介素4在炎症性肠病与黏膜免疫反应性中的作用
Gastroenterology. 1996 Jun;110(6):1683-95. doi: 10.1053/gast.1996.v110.pm8964392.
6
Intestinal epithelial cells both express and respond to interleukin 15.肠道上皮细胞既能表达白细胞介素15，又能对其作出反应。
Gastroenterology. 1996 Dec;111(6):1706-13. doi: 10.1016/s0016-5085(96)70036-7.
7
Regulatory cytokines in inflammatory bowel disease.
Aliment Pharmacol Ther. 1996;10 Suppl 2:75-9; discussion 80. doi: 10.1046/j.1365-2036.1996.22164024.x.
8
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.炎症性肠病中不同的CD4 +固有层（LP）淋巴细胞因子分泌谱。克罗恩病LP细胞表现出IFN-γ分泌增加，而溃疡性结肠炎LP细胞表现出IL-5分泌增加。
J Immunol. 1996 Aug 1;157(3):1261-70.
9
Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12.在实验性结肠炎中，小鼠对肠道常驻菌群的耐受性被消除，而通过白细胞介素-10或抗白细胞介素-12抗体治疗可恢复这种耐受性。
Eur J Immunol. 1996 Apr;26(4):934-8. doi: 10.1002/eji.1830260432.
10
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.白细胞介素12 p40基因启动子在单核细胞中由γ干扰素启动。
J Exp Med. 1996 Jan 1;183(1):147-57. doi: 10.1084/jem.183.1.147.
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