Vallisa D, Pagani L, Bertè R, Civardi G, Viale P, Paties C, Cavanna L
Division of Internal Medicine, Hospital of Piacenza, Italy.
Tumori. 1998 Jul-Aug;84(4):511-4. doi: 10.1177/030089169808400415.
Human immunodeficiency virus (HIV) is likely to play a role in the onset of plasma cell tumors (PCT). In fact, HIV could be involved in plasmacytomagenesis in several ways: it has the ability to lessen the immunosurveillance to such a degree as to impair the immune response against tumor cell growth. This decreased immunosurveillance could further facilitate the transforming malignant role of possible Epstein-Barr virus (EBV) infection occurring in this setting. Lastly, a murine retrovirus has been shown to be able to accelerate plasmacytomagenesis in mice, thus indicating that these viruses may be directly involved in the onset of PCT. According to cases previously reported in the literature, the clinical features of this case of HIV-associated PCT were more aggressive and the survival was shorter than expected for PCT cases in the general population. Further, the pattern of alteration of gammaglobulinemia differed in this setting. These alterations strongly suggest a direct role of HIV in PCT. Further in-depth investigations are therefore warranted to elucidate this issue.
人类免疫缺陷病毒（HIV）可能在浆细胞瘤（PCT）的发病过程中起作用。事实上，HIV可能通过多种方式参与浆细胞瘤的发生：它能够降低免疫监视，以至于损害针对肿瘤细胞生长的免疫反应。这种免疫监视的降低可能进一步促进在这种情况下可能发生的爱泼斯坦-巴尔病毒（EBV）感染的转化恶性作用。最后，已证明一种鼠逆转录病毒能够加速小鼠浆细胞瘤的发生，因此表明这些病毒可能直接参与PCT的发病。根据文献中先前报道的病例，该例HIV相关PCT的临床特征更具侵袭性，生存期比一般人群中PCT病例的预期生存期更短。此外，在这种情况下，γ球蛋白血症的改变模式有所不同。这些改变强烈提示HIV在PCT中起直接作用。因此，有必要进行进一步深入的研究以阐明这一问题。
