Beck M L, Edwards R L, Pierce S R, Hicklin B L, Bayer W L
Transfusion. 1976 Sep-Oct;16(5):434-6. doi: 10.1046/j.1537-2995.1976.16577039298.x.
Fatty acid dependent agglutinin (FADA) refers to serum with the special ability to cause agglutination of red blood cells in the presence of certain fatty acids. The agglutinating mechanism is unclear. It has been proposed that the agglutinin reacts with albumin that has been conformationally altered by sodium caprylate and that the immune complex is passively adsorbed onto red blood cells. This report presents data that contradicts the proposal assigning a specific role to albumin in the agglutinating mechanism. FADA were isolated by column chromatography of resolubilized euglobulin preparations. No evidence of contamination with albumin was obtained in those IgM fractions possessing FADA activity. We propose, as an alternative explanation, that the serologic activity of FADA depends upon the interaction of IgM agglutinins with haptenic fatty acids.
脂肪酸依赖性凝集素（FADA）是指在某些脂肪酸存在下具有使红细胞凝集特殊能力的血清。其凝集机制尚不清楚。有人提出，凝集素与已被辛酸钠改变构象的白蛋白发生反应，并且免疫复合物被动吸附到红细胞上。本报告提供的数据与在凝集机制中赋予白蛋白特定作用的提议相矛盾。通过对再溶解的优球蛋白制剂进行柱色谱法分离出FADA。在那些具有FADA活性的IgM组分中未获得白蛋白污染的证据。作为一种替代解释，我们提出FADA的血清学活性取决于IgM凝集素与半抗原脂肪酸的相互作用。
