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辛酸依赖型白蛋白抗体的实验诱导

Experimental induction of caprylate-dependent albumin antibodies.

作者信息

Hossaini A A, Hazeghi K, Amiri P

出版信息

Transfusion. 1977 Jan-Feb;17(1):54-8. doi: 10.1046/j.1537-2995.1977.17177128886.x.

DOI:10.1046/j.1537-2995.1977.17177128886.x
PMID:841674
Abstract

To provide evidence for the immune nature of the albumin agglutination phenomenon or caprylate dependent albumin agglutinins (CDAA), rabbits were injected with native serum that had been incubated in a solution of sodium caprylate. Two of three rabbits responded with the production of CDAA, which in vitro behaved identical to human antisera. Human cells were agglutinated only when caprylate stabilized albumin was added to the cell/serum mixture or when caprylate free albumin plus sodium caprylate were used. The CDAA failed to agglutinate rabbit cells, although, both human adult and cord cells were agglutinated. These experiments indicate that the CDAA represent an immune response to native albumin that had been altered by caprylate.

摘要

为了为白蛋白凝集现象或辛酸依赖的白蛋白凝集素(CDAA)的免疫性质提供证据,给兔子注射在辛酸钠溶液中孵育过的天然血清。三只兔子中有两只产生了CDAA,其在体外的表现与人类抗血清相同。只有当将辛酸稳定化的白蛋白添加到细胞/血清混合物中,或者使用无辛酸白蛋白加辛酸钠时,人类细胞才会被凝集。尽管人类成人细胞和脐带细胞都能被凝集,但CDAA不能凝集兔细胞。这些实验表明,CDAA代表了对被辛酸改变的天然白蛋白的免疫反应。

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