Galabov A S, Nikolaeva L, Todorova D, Milkova T
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Z Naturforsch C J Biosci. 1998 Sep-Oct;53(9-10):883-7. doi: 10.1515/znc-1998-9-1017.
Cholesteryl 3",4"-dimethoxycinnamate (7) and a new synthesized o-coumaroyl ester of 3 beta-(2'-hydroxyethoxy)-cholest-5-en (13) exhibited a marked activity against poliovirus type 1 (Mahoney). Compound 7 showed an approximately 20-fold greater selectivity in its antiviral activity than compound 13. These compounds were selected from thirteen steryl esters of cinnamic acid derivatives through an in vitro antiviral screening against viruses belonging to taxonomic groups with causative agents of important human infectious diseases to which chemotherapy is indicated, i.e. Picornaviridae, Orthomyxoviridae, Paramyxoviridae and Herpesviridae.
胆甾醇3'',4''-二甲氧基肉桂酸酯（7）和新合成的3β-(2'-羟基乙氧基)-胆甾-5-烯的邻香豆酰酯（13）对1型脊髓灰质炎病毒（马奥尼株）表现出显著活性。化合物7在抗病毒活性方面的选择性比化合物13高约20倍。这些化合物是从13种肉桂酸衍生物的甾醇酯中，通过针对属于具有重要人类传染病病原体的分类学组的病毒进行体外抗病毒筛选而选出的，这些病原体需要化疗，即小核糖核酸病毒科、正粘病毒科、副粘病毒科和疱疹病毒科。
