青藤碱的肉桂酰和羟基肉桂酰酰胺及其抗氧化和抗病毒活性。
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
作者信息
Spasova Maya, Philipov Stefan, Nikolaeva-Glomb L, Galabov A S, Milkova Ts
机构信息
South-West University, Neofit Rilski, Blagoevgrad 2700, Bulgaria.
出版信息
Bioorg Med Chem. 2008 Aug 1;16(15):7457-61. doi: 10.1016/j.bmc.2008.06.010. Epub 2008 Jun 13.
The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups.
阿朴啡生物碱青藤碱已被转化为3-氨甲基青藤碱，其游离氨基已与肉桂酸、阿魏酸、芥子酸、邻香豆酸和对香豆酸相连。通过DPPH（*）测试研究了合成酰胺的抗氧化潜力。所有测试化合物均表现出比青藤碱和3-氨甲基青藤碱更高的自由基清除活性，且抗氧化效果低于游离羟基肉桂酸。对新合成的化合物进行了体外抗不同分类群病毒的抗病毒活性测试。
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