Weusten B L, van de Wiel A
Department of Internal Medicine, Eemland Hospital, Amersfoort, The Netherlands.
Neth J Med. 1998 Oct;53(4):172-5. doi: 10.1016/s0300-2977(98)00096-5.
Aphthous ulcers of the oral cavity are frequently encountered in general practice. Although the exact pathophysiology remains obscure, many factors can contribute to the pathogenesis of these lesions, such as immunological factors, local trauma, smoking, stress, hormonal state, family history, food hypersensitivity, and infection. We describe three patients in whom a clear relationship appeared to exist between recurrent aphthous ulcers and a deficiency of vitamin B12. It is concluded that in all patients with recurrent aphthous ulceration, deficiency of vitamin B12 should be considered.
口腔阿弗他溃疡在普通临床实践中经常遇到。尽管确切的病理生理机制仍不清楚，但许多因素可导致这些病变的发病机制，如免疫因素、局部创伤、吸烟、压力、激素状态、家族史、食物过敏和感染。我们描述了三名复发性阿弗他溃疡与维生素B12缺乏之间似乎存在明确关联的患者。得出的结论是，对于所有复发性口腔溃疡患者，都应考虑维生素B12缺乏的情况。
