慢性肝炎和肝硬化与酒精摄入、乙型和丙型肝炎以及丁型病毒感染的关系：阿尔巴尼亚的一项病例对照研究
The relationships of chronic hepatitis and cirrhosis to alcohol intake, hepatitis B and C, and delta virus infection: a case-control study in Albania.
作者信息
Kondili L A, Tosti M E, Szklo M, Costantino A, Cotichini R, Resuli B, Rapicetta M, Mele A
机构信息
Laboratorio di Virologia, Istituto Superiore di Sanità, Roma, Italia.
出版信息
Epidemiol Infect. 1998 Oct;121(2):391-5. doi: 10.1017/s0950268898001216.
The present study examined the effect of hepatitis B virus (HBV) and alcohol intake, and the role of hepatitis delta virus (HDV) and hepatitis C virus (HCV) in the aetiology of chronic liver disease in Albania. A total of 106 cases of liver cirrhosis or chronic hepatitis were compared to 195 control patients without these or other liver diseases. Adjusted odds ratios were 52.7 (95% CI 22.7-122) for HBV surface antigen, 26.9 (95% CI 4.9-147) for anti-HCV, 26.2 (95% CI 3-1-221) for anti-HDV, 2.4 (95% CI 1.3-4.4) for lifetime alcohol intake and 2.3 (95% CI 1-5.5) for duration of alcohol intake. Although not significant, an interaction was suggested between HBsAg and anti-HCV and between HBsAg and alcohol intake. Our study underlines the role of hepatitis viruses in the development of chronic liver diseases. Additionally, it suggests that heavy alcohol intake may magnify the effect of HBV on these diseases. HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.
本研究调查了乙型肝炎病毒（HBV）和酒精摄入的影响，以及丁型肝炎病毒（HDV）和丙型肝炎病毒（HCV）在阿尔巴尼亚慢性肝病病因学中的作用。共将106例肝硬化或慢性肝炎病例与195例无这些或其他肝脏疾病的对照患者进行了比较。HBV表面抗原的校正比值比为52.7（95%置信区间22.7 - 122），抗HCV为26.9（95%置信区间4.9 - 147），抗HDV为26.2（95%置信区间3.1 - 221），终生酒精摄入量为2.4（95%置信区间1.3 - 4.4），酒精摄入持续时间为2.3（95%置信区间1 - 5.5）。虽然不显著，但提示HBsAg与抗HCV之间以及HBsAg与酒精摄入之间存在相互作用。我们的研究强调了肝炎病毒在慢性肝病发展中的作用。此外，研究表明大量饮酒可能会放大HBV对这些疾病的影响。HBV疫苗接种和戒酒似乎是降低阿尔巴尼亚肝硬化和慢性肝炎风险的重要策略。
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