Ciccone E, Truini M, Grossi C E
National Institute for Cancer Research, Genoa, Italy.
Eur J Morphol. 1998 Aug;36 Suppl:252-6.
In normal human salivary glands the Duct-Associated Lymphoid Tissue (DALT) is poorly developed. In contrast, in the course of autoimmune disorders, typified by Sjögren's syndrome (SS), organized lymphoid accumulations are formed around the ducts. B cell-dependent zones with secondary follicles and T cell-dependent zones with HEV are detected in these lymphoid structures. In addition, the duct epithelium is infiltrated by abundant lymphocytes. A persistent antigenic stimulation may lead to development of B-cell Mucosa-Associated Lymphoid Tissue (MALT) lymphomas that, in low-grade cases, maintain the lobular organization of normal and of SS salivary glands.
在正常人类唾液腺中，导管相关淋巴组织（DALT）发育不良。相比之下，在以干燥综合征（SS）为代表的自身免疫性疾病过程中，导管周围会形成有组织的淋巴聚集。在这些淋巴结构中可检测到带有次级滤泡的B细胞依赖区和带有高内皮微静脉的T细胞依赖区。此外，导管上皮有大量淋巴细胞浸润。持续的抗原刺激可能导致B细胞黏膜相关淋巴组织（MALT）淋巴瘤的发生，在低度病例中，其维持正常和SS唾液腺的小叶结构。
