Nachmanoff D B, Panigrahy A, Filiano J J, Mandell F, Sleeper L A, Valdes-Dapena M, Krous H F, White W F, Kinney H C
Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.
J Neuropathol Exp Neurol. 1998 Nov;57(11):1018-25. doi: 10.1097/00005072-199811000-00004.
Maternal cigarette smoking during pregnancy has been shown to be a major risk factor for the sudden infant death syndrome (SIDS). We hypothesized that SIDS is associated with altered 3H-nicotine binding to nicotinic receptors in brainstem nuclei related to cardiorespiratory control and/or arousal. We analyzed 3H-nicotine binding in 14 regions in SIDS and control brainstems using quantitative tissue receptor autoradiography. Three groups were analyzed: SIDS (n = 42), acute controls (n = 15), and a chronic group with oxygenation disorders (n = 18). The arcuate nucleus, postulated to be important in cardiorespiratory control and abnormal in at least some SIDS victims, contained binding below the assay detection limits in all (SIDS and control) cases. We found no significant differences among the 3 groups in mean 3H-nicotine binding in the 14 brainstem sites analyzed. When a subset of the cases were stratified by the history of the presence or absence of maternal cigarette smoking during pregnancy, however, we found that there was no expected increase (upregulation) of nicotinic receptor binding in SIDS cases exposed to cigarette smoke in utero in 3 nuclei related to arousal or cardiorespiratory control. This finding raises the possibility that altered development of nicotinic receptors in brainstem cardiorespiratory and/or arousal circuits put at least some infants, i.e. those exposed to cigarette smoke in utero, at risk for SIDS, and underscores the need for further research into brainstem nicotinic receptors in SIDS in which detailed correlations with smoking history can be made.
孕期母亲吸烟已被证明是婴儿猝死综合征（SIDS）的主要危险因素。我们推测，SIDS与脑干核中3H-尼古丁与烟碱受体的结合改变有关，这些脑干核与心肺控制和/或觉醒相关。我们使用定量组织受体放射自显影技术分析了SIDS组和对照组脑干中14个区域的3H-尼古丁结合情况。分析了三组：SIDS组（n = 42）、急性对照组（n = 15）和慢性氧合障碍组（n = 18）。弓状核被认为在心肺控制中起重要作用，且至少在一些SIDS受害者中存在异常，在所有（SIDS组和对照组）病例中，其结合水平低于检测限。在分析的14个脑干部位，我们发现三组之间的平均3H-尼古丁结合没有显著差异。然而，当根据孕期母亲是否吸烟的病史对部分病例进行分层时，我们发现在与觉醒或心肺控制相关的3个核中，宫内暴露于香烟烟雾的SIDS病例中，烟碱受体结合并没有预期的增加（上调）。这一发现增加了一种可能性，即脑干心肺和/或觉醒回路中烟碱受体的发育改变使至少一些婴儿，即那些宫内暴露于香烟烟雾的婴儿，面临SIDS的风险，并强调了对SIDS中脑干烟碱受体进行进一步研究的必要性，在这类研究中可以与吸烟史进行详细的相关性分析。
