沙眼衣原体IncA定位于包涵体膜，可被来自受感染人类和灵长类动物的抗血清识别。
Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates.
作者信息
Bannantine J P, Stamm W E, Suchland R J, Rockey D D
机构信息
Department of Microbiology, Oregon State University, Corvallis, Oregon 97331-3804, USA.
出版信息
Infect Immun. 1998 Dec;66(12):6017-21. doi: 10.1128/IAI.66.12.6017-6021.1998.
Abstract
Chlamydia psittaci produces a collection of proteins, termed IncA, IncB, and IncC, that are localized to the chlamydial inclusion membrane. In this report we demonstrate that IncA is also produced by Chlamydia trachomatis. C. trachomatis IncA is structurally similar to C. psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA.
摘要
鹦鹉热衣原体产生一组蛋白质，称为IncA、IncB和IncC，它们定位于衣原体包涵体膜。在本报告中，我们证明沙眼衣原体也产生IncA。沙眼衣原体IncA在结构上与鹦鹉热衣原体IncA相似，也定位于包涵体膜。免疫印迹分析表明，沙眼衣原体感染患者和实验感染猴子的血清均能识别沙眼衣原体IncA。
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本文引用的文献
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Tandem genes of Chlamydia psittaci that encode proteins localized to the inclusion membrane.编码定位于包涵体膜的蛋白质的鹦鹉热衣原体串联基因。
Mol Microbiol. 1998 Jun;28(5):1017-26. doi: 10.1046/j.1365-2958.1998.00867.x.
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Chlamydia psittaci IncA is phosphorylated by the host cell and is exposed on the cytoplasmic face of the developing inclusion.鹦鹉热衣原体IncA被宿主细胞磷酸化，并暴露于正在形成的包涵体的细胞质面。
Mol Microbiol. 1997 Apr;24(1):217-28. doi: 10.1046/j.1365-2958.1997.3371700.x.
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The Chlamydia trachomatis parasitophorous vacuolar membrane is not passively permeable to low-molecular-weight compounds.沙眼衣原体包涵体膜对低分子量化合物并非被动通透。
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Vesicular interactions of the Chlamydia trachomatis inclusion are determined by chlamydial early protein synthesis rather than route of entry.沙眼衣原体包涵体的囊泡相互作用取决于衣原体早期蛋白质合成，而非进入途径。
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The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins.晚期衣原体包涵体膜并非源自内吞途径，且宿主蛋白相对缺乏。
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Sphingolipids and glycoproteins are differentially trafficked to the Chlamydia trachomatis inclusion.鞘脂和糖蛋白被不同地转运至沙眼衣原体包涵体。
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The cell biology of infection by intracellular bacterial pathogens.细胞内细菌病原体感染的细胞生物学
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Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis.与内吞和外排途径的差异相互作用区分了伯纳特柯克斯体和沙眼衣原体的吞噬泡。
Infect Immun. 1996 Mar;64(3):796-809. doi: 10.1128/iai.64.3.796-809.1996.
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