Gravestein L A, Borst J
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.
Semin Immunol. 1998 Dec;10(6):423-34. doi: 10.1006/smim.1998.0144.
The tumor necrosis factor (TNF) receptor family contains death receptors, which have a cytoplasmic death domain and can induce apoptosis, as well as receptors with no apparent homology in the cytoplasmic tail. This second group of receptors binds TNF receptor-associated factors (TRAFs), which are implicated in gene regulation and anti-apoptotic signaling. A bewildering variety of TNF receptor family members and their ligands are expressed on cells of the immune system. Based on the pattern of expression of receptors and ligands and based on the phenotype of available knock out mice, we summarize at which stages in lymphoid development and/or the peripheral immune response the various TNF receptor family members may play a role.
肿瘤坏死因子（TNF）受体家族包含死亡受体，其具有细胞质死亡结构域并可诱导细胞凋亡，以及在细胞质尾部无明显同源性的受体。第二组受体结合TNF受体相关因子（TRAFs），这些因子参与基因调控和抗凋亡信号传导。免疫系统细胞上表达了各种各样令人眼花缭乱的TNF受体家族成员及其配体。基于受体和配体的表达模式以及现有基因敲除小鼠的表型，我们总结了各种TNF受体家族成员可能在淋巴细胞发育和/或外周免疫反应的哪些阶段发挥作用。
