Pawlowski P, Gallo S A, Johnson P G, Hui S W
Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263 USA.
Biophys J. 1998 Dec;75(6):2721-31. doi: 10.1016/S0006-3495(98)77716-1.
Experimentally observed changes in the conductivity of skin under the influence of a pulsing electric field were theoretically analyzed on the basis of a proposed electrorheological model of the stratum corneum (SC). The dependence of relative changes in conductivity on the amplitude of electric field and timelike parameters of applied pulses or pulse trains have been mathematically described. Statistical characteristics of phenomena of transient and long-term electroporation of SC were taken into consideration. The time-dependent decreases of skin resistance depicted by the models were fitted to experimental data for transient and long-term skin permeabilization by electric pulses. The results show two characteristic times and two spectra of characteristic energies for transient and long-term permeabilizations. The rheological parameters derived from the fittings agreed with those reported elsewhere for biological membranes.
基于所提出的角质层（SC）电流变模型，从理论上分析了在脉冲电场影响下实验观察到的皮肤电导率变化。数学描述了电导率的相对变化与电场幅度以及所施加脉冲或脉冲序列的时间参数之间的依赖关系。考虑了SC瞬态和长期电穿孔现象的统计特征。模型所描述的皮肤电阻随时间的下降与电脉冲引起的瞬态和长期皮肤通透性实验数据相拟合。结果显示了瞬态和长期通透性的两个特征时间和两个特征能量谱。从拟合中得出的流变参数与其他地方报道的生物膜流变参数一致。
