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T cell receptor antagonism in vivo, at last.终于实现了体内T细胞受体拮抗作用。
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14001-2. doi: 10.1073/pnas.95.24.14001.
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Fine specificity of myelin basic protein reactive T-cells: implications for T-cell receptor antagonism.
Biochem Soc Trans. 1997 May;25(2):659-61. doi: 10.1042/bst0250659.
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Novel subsets of human T cells (CD4+ CD8- TCR gamma delta and CD4- CD8- TCR alpha beta) and T-cell development.
Int J Cancer Suppl. 1989;4:43-7.
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Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivo.在体内，增殖的CD4+ T细胞在TCR信号停止后立即进入生长停滞状态。
J Immunol. 2008 Jan 1;180(1):156-62. doi: 10.4049/jimmunol.180.1.156.
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Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities.前沿：对抗性T细胞受体：具有双重抗原特异性的CD4+ T细胞的肽拮抗作用
J Immunol. 1999 Aug 15;163(4):1750-4.
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Receptors and ligands that mediate activation-induced death of T cells.介导T细胞活化诱导死亡的受体和配体。
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Functional reprogramming of the primary immune response by T cell receptor antagonism.通过T细胞受体拮抗作用对初次免疫反应进行功能重编程。
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Functional uncoupling of T-cell receptor engagement and Lck activation in anergic human thymic CD4+ T cells.无反应性人类胸腺CD4⁺ T细胞中T细胞受体结合与Lck激活的功能解偶联
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本文引用的文献

1
In vivo antagonism of a T cell response by an endogenously expressed ligand.内源性表达的配体对T细胞反应的体内拮抗作用。
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14332-6. doi: 10.1073/pnas.95.24.14332.
2
Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells.预选胸腺细胞比成熟T细胞对T细胞受体刺激更敏感。
J Exp Med. 1998 Nov 16;188(10):1867-74. doi: 10.1084/jem.188.10.1867.
3
Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage.拮抗肽将表达Ⅱ类主要组织相容性复合体限制的T细胞受体的胸腺细胞选择进入CD8谱系。
J Exp Med. 1998 Sep 21;188(6):1083-9. doi: 10.1084/jem.188.6.1083.
4
Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.通过多步骤T细胞受体ζ磷酸化实现T细胞激活的保真度
Science. 1998 Jul 24;281(5376):572-5. doi: 10.1126/science.281.5376.572.
5
Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.改变的肽配体在原代胸腺细胞中诱导出数量上而非质量上不同的细胞内信号。
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8193-8. doi: 10.1073/pnas.95.14.8193.
6
In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery.
J Immunol. 1998 Jul 1;161(1):128-37.
7
CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.未成熟胸腺细胞上的CD3连接产生适合CD8谱系定向的拮抗性样信号，与T细胞受体特异性无关。
J Exp Med. 1998 Apr 20;187(8):1249-60. doi: 10.1084/jem.187.8.1249.
8
Association of malaria parasite population structure, HLA, and immunological antagonism.疟原虫种群结构、人类白细胞抗原（HLA）与免疫拮抗作用的关联
Science. 1998 Feb 20;279(5354):1173-7. doi: 10.1126/science.279.5354.1173.
9
Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo.采用T细胞抗原受体转基因T细胞的过继转移来研究体内T细胞活化。
Immunol Rev. 1997 Apr;156:67-78. doi: 10.1111/j.1600-065x.1997.tb00959.x.
10
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.CD8增强稳定的T细胞受体/MHC I类分子复合物的形成。
Nature. 1996 Dec 12;384(6609):577-81. doi: 10.1038/384577a0.

T cell receptor antagonism in vivo, at last.

作者信息

Jameson S C

机构信息

Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 312 Church Street SE, Minneapolis, MN 55455, USA.

出版信息

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14001-2. doi: 10.1073/pnas.95.24.14001.

DOI:10.1073/pnas.95.24.14001
PMID:9826640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33920/
Abstract
摘要