Ember I, Kiss I, Raposa T, Nowrasteh G, Matolcsy A
Department of Preventive Medicine, University Medical School of Pécs, Hungary.
In Vivo. 1998 Sep-Oct;12(5):489-94.
In vivo investigation of onco/suppressor gene effects may provide new findings concerning chemical carcinogenesis. In earlier studies we pointed out the carcinogenic potential of COPP and ABVD chemotherapeutical protocols in "long-term" experiments. In another follow up study we proved the connection between the early gene expression changes and the late consequences of COPP and ABVD treatment during, a one year latency period. CHOP protocol is containing both proved carcinogenic cyclophosphamide and highly mutagenic doxorubicyn. CHOP protocol in "short-term" experiments shows strong effect on Ha-ras oncogene expression.
对癌基因/抑癌基因效应进行体内研究可能会为化学致癌作用提供新的发现。在早期研究中，我们指出了COPP和ABVD化疗方案在“长期”实验中的致癌潜力。在另一项后续研究中，我们证明了在一年的潜伏期内，COPP和ABVD治疗的早期基因表达变化与晚期后果之间的联系。CHOP方案既包含已证实具有致癌性的环磷酰胺，又包含具有高度致突变性的阿霉素。CHOP方案在“短期”实验中对Ha-ras癌基因表达显示出强烈影响。
