Ember I, Kiss I, Raposa T
Department of Preventive Medicine, University Medical School of Pécs, Hungary.
In Vivo. 1997 Sep-Oct;11(5):399-402.
In vivo investigation of onco or suppressor genes may provide new information concerning chemical carcinogenesis. In earlier studies we illustrated the carcinogenic potential of COPP chemotherapeutical protocol in "long term" experiments. Elevated expression of oncogenes was shown as soon as 24 hours after treatment in CBA/Ca inbred mice, in "short term" experiments. Now we present the results of the follow-up study dealing with the carcinogenic effect of COPP. The genes most frequently involved were N-ras and p53, with the thymus being the target organ of COPP.
对癌基因或抑癌基因进行体内研究可能会提供有关化学致癌作用的新信息。在早期研究中，我们在“长期”实验中阐明了COPP化疗方案的致癌潜力。在“短期”实验中，CBA/Ca近交系小鼠在治疗后24小时就出现了癌基因表达升高的情况。现在我们展示了关于COPP致癌作用的后续研究结果。最常涉及的基因是N-ras和p53，胸腺是COPP的靶器官。
