Noël B
Division d'Hypertension et de Médecine Vasculaire, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.
J Mal Vasc. 1998 Oct;23(4):251-6.
The vibration syndrome is an often unrecognized occupational neurovascular disease with a prevalence of more than 70% in certain high-risk occupations. Early recognition is crucial because continued exposure to vibration can lead to irreversible ischemic injury and loss of digits. Digital ischemia due to the vibration syndrome may be due to a vasospastic phenomenon, an organic microangiopathy or arterial thrombosis. Demyelinating neuropathy and carpal tunnel syndrome are often associated. Many pathophysiological mechanisms are implicated: hyperactivity of the central sympathetic nervous system, release of plasma endothelin-1 and loss of calcitonin-gene-related-peptide vasoregulation. Investigation tests, treatment and the European Community Directive for the protection of workers are also presented.
振动综合征是一种常未被认识的职业性神经血管疾病，在某些高危职业中的患病率超过70%。早期识别至关重要，因为持续接触振动会导致不可逆的缺血性损伤和手指丧失。振动综合征所致的手指缺血可能是由于血管痉挛现象、器质性微血管病或动脉血栓形成。脱髓鞘性神经病和腕管综合征常相伴发生。许多病理生理机制与之相关：中枢交感神经系统功能亢进、血浆内皮素-1释放以及降钙素基因相关肽血管调节功能丧失。文中还介绍了相关的检查测试、治疗方法以及欧洲共同体保护工人的指令。
