Spieker S, Boose A, Breit S, Dichgans J
Department of Neurology, University of Tübingen, Germany.
Mov Disord. 1998;13 Suppl 3:81-4. doi: 10.1002/mds.870131314.
To account for the fluctuating and context-dependent nature of tremor, the method of ambulatory long-term electromyography (EMG) was developed for quantification of this symptom. It is based on successive evaluation of 15-s intervals by using a fast Fourier transformation (FFT). The standard results obtained are (a) tremor occurrence, a measure of how many intervals contain tremor; (b) mean tremor intensity; and (v) mean tremor frequency. This new method fulfills the so-called "test criteria" such as reliability, validity, sensitivity, and specificity for tremor quantification in essential tremor (ET) and Parkinson's disease (PD). In addition, we developed a method of determining the antagonist activation pattern by using cross-correlation analysis, also based on the long-term approach. This allows differentiation between ET and PD with a high sensitivity and a high interrater reliability. We conclude that long-term EMG is useful for both quantification and differentiation of tremor.
为了考虑震颤的波动特性和与上下文相关的性质，开发了动态长期肌电图（EMG）方法来量化这种症状。它基于使用快速傅里叶变换（FFT）对15秒间隔进行连续评估。获得的标准结果包括：（a）震颤发生率，即包含震颤的间隔数量的度量；（b）平均震颤强度；以及（v）平均震颤频率。这种新方法满足了所谓的“测试标准”，如在特发性震颤（ET）和帕金森病（PD）中对震颤量化的可靠性、有效性、敏感性和特异性。此外，我们还开发了一种同样基于长期方法的互相关分析来确定拮抗肌激活模式的方法。这使得能够以高敏感性和高评分者间可靠性区分ET和PD。我们得出结论，长期肌电图对于震颤的量化和鉴别都很有用。
