Pullman S L
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mov Disord. 1998;13 Suppl 3:85-9. doi: 10.1002/mds.870131315.
A new computational method for quantification of tremor and other aspects of motor dysfunction is described. By using a digitizing tablet connected to a microcomputer, this analysis is derived from the handwritten Archimedean spiral. This technique extends the standard clinical neurologic test of spiral drawing into an objective and accurate measure that can automatically detect, characterize, and quantify motor dysfunction in patients with movement disorders. Further, it is safe, inexpensive, fast, portable, noninvasive, and can be administered to a large cohort of patients without the need for wires or other attachments. Spiral data are collected in the X, Y, and pressure axes, providing virtual "triaxial" recordings. Spiral analysis is shown to be capable of assessing subtle motor abnormalities potentially indicative of clinical problems in their earliest stages, and thus allow the most rational forms of genetic testing, treatment, or prevention. Spiral analysis may be useful as an initial marker of clinical involvement or serve as an objective gauge of change after therapeutic intervention.
本文描述了一种用于量化震颤及运动功能障碍其他方面的新计算方法。通过使用连接到微型计算机的数字化平板电脑，该分析源自手写的阿基米德螺旋线。这项技术将标准的螺旋线绘制临床神经学测试扩展为一种客观、准确的测量方法，能够自动检测、表征和量化运动障碍患者的运动功能障碍。此外，它安全、廉价、快速、便携、无创，并且无需电线或其他附件即可应用于大量患者。螺旋线数据在X、Y和压力轴上收集，提供虚拟的“三轴”记录。螺旋线分析能够评估可能在最早阶段就指示临床问题的细微运动异常，从而实现最合理的基因检测、治疗或预防形式。螺旋线分析可能作为临床受累的初始标志物有用，或作为治疗干预后变化的客观指标。
