IFI60/ISG60/IFIT4，人干扰素刺激基因IFI54/IFIT2家族的一个新成员。
IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.
作者信息
de Veer M J, Sim H, Whisstock J C, Devenish R J, Ralph S J
机构信息
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3168, Australia.
出版信息
Genomics. 1998 Dec 1;54(2):267-77. doi: 10.1006/geno.1998.5555.
We report the cloning and sequencing of a full-length cDNA encoding a new member of the human IFI54 (HGMW-approved symbol IFIT2) gene family, designated IFI60 (HGMW-approved symbol IFIT4). The upstream regulatory region of IFI60 shows conservation in structure with that of the IFI54 and IFI56 (HGMW-approved symbol IFIT1) genes, each containing two interferon-stimulated response elements upstream of a conserved TATA box. We have established a partial gene map of the IFI54 gene family by analysis of YAC library clones. All four members of the human family are clustered together at chromosome 10q23.3. It is proposed that the four members of the IFI54 gene family evolved by a series of duplication events from a common gene of origin.
我们报道了编码人IFI54（HGMW批准符号IFI T2）基因家族一个新成员的全长cDNA的克隆和测序，该新成员命名为IFI60（HGMW批准符号IFI T4）。IFI60的上游调控区域在结构上与IFI54和IFI56（HGMW批准符号IFI T1）基因的上游调控区域具有保守性，每个基因在保守的TATA框上游均含有两个干扰素刺激反应元件。我们通过分析酵母人工染色体（YAC）文库克隆建立了IFI54基因家族的部分基因图谱。人类家族的所有四个成员都聚集在染色体10q23.3上。有人提出，IFI54基因家族的四个成员是通过一系列复制事件从一个共同的起源基因进化而来的。
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