Brouwer A, Ahlborg U G, van Leeuwen F X, Feeley M M
Dept. of Toxicology, Wageningen Agricultural University, Netherlands.
Chemosphere. 1998 Oct-Nov;37(9-12):1627-43. doi: 10.1016/s0045-6535(98)00230-6.
On Nov. 20-22, 1995, a World Health Organization working group consisting of 12 scientific representatives from 6 different countries met to reassess the health risks to infants associated with perinatal exposure to polyhalogenated aromatic hydrocarbons (PHAHs). Following a review of previous WHO/EURO consultations, as part of their comprehensive programme on PCDDs, PCDFs and PCBs, current exposure information and recent experimental and epidemiologic data were discussed. Exposure assessments within the past decade have revealed that in the case of breast milk samples concentrations of PCDDs/DFs and PCBs have shown a continual decline, in certain countries by up to 50%. New experimental data has revealed that a variety of structural, functional and behaviourial alterations can be induced in rodent species following exposure to PHAHs while a Dutch collaborative PCB/dioxin study has illustrated subtle clinical, endocrine and mental/psychomotor development effects can occur in breast fed infants. The provisional conclusions of the working group were: 1) current evidence does not warrant altering the previous WHO recommendation for promotion/support of breast feeding and 2) based on new clinical data which supports the biological plausibility of certain observed experimental observations, continued and enhanced effort should be directed towards identifying and controlling sources of environmental input for these contaminants.
1995年11月20日至22日，一个由来自6个不同国家的12名科学代表组成的世界卫生组织工作组召开会议，重新评估围产期接触多卤代芳烃（PHAHs）对婴儿健康的风险。在回顾了世卫组织/欧洲区域办事处以前的磋商情况后，作为其关于多氯二苯并对二恶英、多氯二苯并呋喃和多氯联苯综合计划的一部分，讨论了当前的接触信息以及最新的实验和流行病学数据。过去十年的接触评估表明，就母乳样本而言，多氯二苯并对二恶英/呋喃和多氯联苯的浓度持续下降，在某些国家下降幅度高达50%。新的实验数据表明，啮齿动物接触多卤代芳烃后会出现各种结构、功能和行为改变，而荷兰一项关于多氯联苯/二恶英的合作研究表明，母乳喂养的婴儿可能会出现轻微的临床、内分泌和心理/精神运动发育影响。工作组的初步结论是：1）目前的证据不足以改变世卫组织先前关于促进/支持母乳喂养的建议；2）基于支持某些观察到的实验结果生物学合理性的新临床数据，应继续并加大力度识别和控制这些污染物的环境输入源。
