Tubridy N, Barker G J, Macmanus D G, Moseley I F, Miller D H
NMR Research Unit, Institute of Neurology, London, UK.
Br J Radiol. 1998 Aug;71(848):840-5. doi: 10.1259/bjr.71.848.9828796.
Two-dimensional (2D) fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging is superior to T2 weighted conventional spin echo (CSE), in certain areas of the brain but not in others, in detecting the lesions of multiple sclerosis (MS). The present study evaluates the ability of a recently developed three-dimensional fast FLAIR (3D fast FLAIR) sequence in detecting and quantifying the brain lesions of multiple sclerosis. The lesion volumes measured on the 3D fast FLAIR sequence with 1.5 mm thick slices were compared with those obtained from CSE brain images with 5 mm thick slices. The findings seen in 3D fast FLAIR brain images in 10 normal control subjects are also described. 3D fast FLAIR images showed an overall increase of 34% in lesion volume compared with CSE. The increase was most marked in the periventricular and "discrete" areas of the cerebral hemispheres. Lesion volumes seen in the subcortical areas were similar in both sequences. The CSE images displayed higher lesion volumes in the posterior cranial fossa. It is concluded that 3D fast FLAIR is a promising technique for quantifying cerebral pathology in MS which is not accessible to 2D CSE.
二维（2D）液体衰减反转恢复（FLAIR）磁共振成像在检测多发性硬化症（MS）的脑损伤方面，在某些脑区优于传统的T2加权自旋回波（CSE）成像，而在其他脑区则不然。本研究评估了一种最近开发的三维快速FLAIR（3D快速FLAIR）序列检测和量化多发性硬化症脑损伤的能力。将在1.5毫米厚切片的3D快速FLAIR序列上测量的损伤体积与在5毫米厚切片的CSE脑图像上获得的损伤体积进行比较。还描述了10名正常对照受试者的3D快速FLAIR脑图像中的发现。与CSE相比，3D快速FLAIR图像显示损伤体积总体增加了34%。这种增加在脑室周围和大脑半球的“离散”区域最为明显。两个序列在皮质下区域看到的损伤体积相似。CSE图像在后颅窝显示出更高的损伤体积。得出的结论是，3D快速FLAIR是一种有前途的技术，可用于量化二维CSE无法检测到的MS脑病变。
