Knapp M, Marks I, Wolstenholme J, Beecham J, Astin J, Audini B, Connolly J, Watts V
Institute of Psychiatry, Centre for the Economics of Mental Health, London, UK.
Br J Psychiatry. 1998 Jun;172:506-12. doi: 10.1192/bjp.172.6.506.
The Daily Living Programme (DLP) offered intensive home-based care with problem-centred case management for seriously mentally ill people facing crisis admission to the Maudsley Hospital, London. The cost-effectiveness of the DLP was examined over four years.
A randomised controlled study examined cost-effectiveness of DLP versus standard in/out-patient hospital care over 20 months, followed by a randomised controlled withdrawal of half the DLP patients into standard care. Three patient groups were compared over 45 months: DLP throughout the period, DLP for 20 months followed by standard care, and standard care throughout. Bivariate and multivariate analyses were conducted (the latter to standardise for possible inter-sample differences stemming from sample attrition and to explore sources of within-sample variation).
The DLP was more cost-effective than control care over months 1-20, and also over the full 45-month period, but the difference between groups may have disappeared by the end of month 45.
The reduction of the cost-effectiveness advantage for home-based care was perhaps partly due to the attenuation of DLP care, although sample attrition left some comparisons under-powered.
日常生活项目(DLP)为面临被伦敦莫兹利医院危机收治的重症精神病患者提供以问题为中心的强化居家护理及病例管理。对DLP的成本效益进行了为期四年的研究。
一项随机对照研究在20个月内考察了DLP与标准住院/门诊医院护理相比的成本效益,随后将一半的DLP患者随机对照撤回至标准护理。在45个月内对三组患者进行了比较:整个期间接受DLP护理、接受20个月DLP护理后转为标准护理、以及全程接受标准护理。进行了双变量和多变量分析(后者用于对因样本损耗可能产生的样本间差异进行标准化,并探索样本内变异的来源)。
在第1至20个月以及整个45个月期间,DLP比对照护理更具成本效益,但到第45个月末,两组之间的差异可能已经消失。
居家护理成本效益优势的降低可能部分归因于DLP护理的减弱,尽管样本损耗使得一些比较的效力不足。