Pillay K
Department of Pediatrics and Child Health, Faculty of Medicine, University of Natal, Republic of South Africa.
J Pediatr Endocrinol Metab. 1998 Nov-Dec;11(6):757-61. doi: 10.1515/jpem.1998.11.6.757.
Bi-directional interactions between the endocrine and immune systems have been well described, particularly in relation to the growth hormone and adrenal axes. The possible effects of the thyroid gland on the immune system have not been clearly elucidated. This report describes a patient with congenital hypothyroidism and immune deficiency characterized by severe and persistent lymphopenia. The clinical course was punctuated by recurrent episodes of respiratory symptoms (in association with bronchiectasis) and diarrhea. The child ultimately died from overwhelming respiratory infection. It is proposed that the prolonged deficiency of thyroid hormone may be directly related to the impairment of the cellular immune system.
内分泌系统与免疫系统之间的双向相互作用已得到充分描述，尤其是与生长激素和肾上腺轴相关的作用。甲状腺对免疫系统的可能影响尚未明确阐明。本报告描述了一名患有先天性甲状腺功能减退症和免疫缺陷的患者，其特征为严重且持续的淋巴细胞减少。临床病程中反复出现呼吸道症状（伴有支气管扩张）和腹泻。该患儿最终死于严重的呼吸道感染。有人提出，甲状腺激素的长期缺乏可能与细胞免疫系统的损害直接相关。
