Kumari Kanchan, Chainy Gagan B N, Subudhi Umakanta
CSIR-Institute of Minerals & Materials Technology, Bhubaneswar 751013, Odisha, India.
Department of Molecular Biology, Umea University, Sweden.
Heliyon. 2020 Dec;6(12):e05712. doi: 10.1016/j.heliyon.2020.e05712. Epub 2020 Dec 13.
COVID-19 pandemic has affected more than 200 countries and 1.3 million individuals have deceased within eleven months. Intense research on COVID-19 occurrence and prevalence enable us to understand that comorbidities play a crucial role in spread and severity of SARS-CoV-2 infection. Chronic kidney disease, diabetes, respiratory diseases and hypertension are among the various morbidities that are prevalent in symptomatic COVID-19 patients. However, the effect of altered thyroid-driven disorders cannot be ignored. Since thyroid hormone critically coordinate and regulate the major metabolism and biochemical pathways, this review is on the potential role of prevailing thyroid disorders in SARS-CoV-2 infection. Direct link of thyroid hormone with several disorders such as diabetes, vitamin D deficiency, obesity, kidney and liver disorders etc. suggests that the prevailing thyroid conditions may affect SARS-CoV-2 infection. Further, we discuss the oxidative stress-induced aging is associated with the degree of SARS-CoV-2 infection. Importantly, ACE2 protein which facilitates the host-cell entry of SARS-CoV-2 using the spike protein, are highly expressed in individuals with abnormal level of thyroid hormone. Altogether, we report that the malfunction of thyroid hormone synthesis may aggravate SARS-CoV-2 infection and thus monitoring the thyroid hormone may help in understanding the pathogenesis of COVID-19.
新冠疫情已影响200多个国家，11个月内有130万人死亡。对新冠病毒发生和流行情况的深入研究使我们明白，合并症在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的传播和严重程度中起着关键作用。慢性肾病、糖尿病、呼吸系统疾病和高血压是有症状的新冠患者中普遍存在的多种疾病。然而，甲状腺功能紊乱的影响也不容忽视。由于甲状腺激素对主要代谢和生化途径起着关键的协调和调节作用，本综述探讨了常见甲状腺疾病在SARS-CoV-2感染中的潜在作用。甲状腺激素与糖尿病、维生素D缺乏、肥胖、肾脏和肝脏疾病等多种疾病存在直接联系，这表明常见的甲状腺疾病可能会影响SARS-CoV-2感染。此外，我们还讨论了氧化应激诱导的衰老与SARS-CoV-2感染程度的关系。重要的是，利用刺突蛋白促进SARS-CoV-2进入宿主细胞的血管紧张素转换酶2（ACE2）蛋白在甲状腺激素水平异常的个体中高度表达。总之，我们报告甲状腺激素合成功能障碍可能会加重SARS-CoV-2感染，因此监测甲状腺激素可能有助于了解新冠病毒疾病的发病机制。
