2型糖尿病患者血清唾液酸水平与视网膜病变之间无关联。

Lack of association between serum sialic acid levels and retinopathy in Type 2 diabetic patients.

作者信息

Deepa R, Rema M, Mohan V

机构信息

Madras Diabetes Research Foundation, Gopalapuram, Chennai, India.

出版信息

Diabetes Res Clin Pract. 1998 Sep;41(3):165-9. doi: 10.1016/s0168-8227(98)00078-3.

DOI:10.1016/s0168-8227(98)00078-3

PMID:9829344

Abstract

Sialic acid, an acetylated derivative of neuraminic acid, is reported to be a marker of micro- and macrovascular complications in diabetic subjects. The purpose of this study was to investigate the association of serum sialic acid and diabetic retinopathy. Serum sialic acid levels were measured in healthy non-diabetic control subjects, Type 2 diabetic patients without retinopathy (No DR), Type 2 diabetic patients with non-proliferative diabetic retinopathy (NPDR) and Type 2 diabetic patients with proliferative diabetic retinopathy (PDR). There was no significant difference in the serum sialic acid levels between the study groups (controls, 2.1 mmol/l; No DR, 2.5 mmol/l; NPDR, 2.2 mmol/l and PDR, 2.3 mmol/l). These results suggest that there is no association between serum sialic acid levels and diabetic retinopathy.

摘要

唾液酸是神经氨酸的乙酰化衍生物，据报道是糖尿病患者微血管和大血管并发症的一个标志物。本研究的目的是调查血清唾液酸与糖尿病视网膜病变之间的关联。对健康非糖尿病对照受试者、无视网膜病变的2型糖尿病患者（无糖尿病视网膜病变）、患有非增殖性糖尿病视网膜病变（NPDR）的2型糖尿病患者以及患有增殖性糖尿病视网膜病变（PDR）的2型糖尿病患者测定血清唾液酸水平。研究组之间的血清唾液酸水平无显著差异（对照组，2.1 mmol/L；无糖尿病视网膜病变，2.5 mmol/L；NPDR，2.2 mmol/L；PDR，2.3 mmol/L）。这些结果表明血清唾液酸水平与糖尿病视网膜病变之间无关联。