韩国2型糖尿病增殖性糖尿病视网膜病变患者血清脂蛋白(a)水平升高。
High serum lipoprotein(a) levels in Korean type 2 diabetic patients with proliferative diabetic retinopathy.
作者信息
Kim C H, Park H J, Park J Y, Hong S K, Yoon Y H, Lee K U
机构信息
Department of Internal Medicine, Asan Medical Center, Seoul, Korea.
出版信息
Diabetes Care. 1998 Dec;21(12):2149-51. doi: 10.2337/diacare.21.12.2149.
OBJECTIVE
To examine the possible association between serum lipoprotein(a) [Lp(a)] concentration and proliferative diabetic retinopathy (PDR) in Korean patients with type 2 diabetes.
RESEARCH DESIGN AND METHODS
A total of 412 Korean outpatients with type 2 diabetes were examined. Diabetic retinopathy was determined by an ophthalmologist using fundoscopic examination. Serum Lp(a) levels were measured by two-site sandwich enzyme-linked immunosorbent assay.
RESULTS
The patients with PDR had higher serum Lp(a) levels than those with no diabetic retinopathy or with nonproliferative diabetic retinopathy (NPDR). Multiple logistic regression analysis showed that high serum Lp(a) levels and the presence of diabetic nephropathy were independent variables having a statistically significant association with PDR.
CONCLUSIONS
Korean type 2 diabetic patients with PDR had higher serum Lp(a) levels versus those with no diabetic retinopathy or with NPDR. Although these results suggest that Lp(a) might play a role in the occlusion of retinal capillaries leading to PDR, further prospective studies are required to prove the causal relationship.
目的
研究韩国2型糖尿病患者血清脂蛋白(a)[Lp(a)]浓度与增殖性糖尿病视网膜病变(PDR)之间的可能关联。
研究设计与方法
共检查了412名韩国2型糖尿病门诊患者。糖尿病视网膜病变由眼科医生通过检眼镜检查确定。血清Lp(a)水平采用双位点夹心酶联免疫吸附测定法测量。
结果
PDR患者的血清Lp(a)水平高于无糖尿病视网膜病变或非增殖性糖尿病视网膜病变(NPDR)的患者。多因素逻辑回归分析显示，高血清Lp(a)水平和糖尿病肾病的存在是与PDR有统计学显著关联的独立变量。
结论
韩国患有PDR的2型糖尿病患者的血清Lp(a)水平高于无糖尿病视网膜病变或患有NPDR的患者。尽管这些结果表明Lp(a)可能在导致PDR的视网膜毛细血管阻塞中起作用，但需要进一步的前瞻性研究来证明因果关系。
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